The present manuscript describes stable, cost effective immediate release tablets of Losartan Potassium (LTK) in combination with Hydrochlorthiazide (HCTZ) which simplified treatment of hypertension particularly in older patients with renal insufficiency. The addition of Hydrochlorthiazide to Losartan Potassium will potentiate the antihypertensive action. Tablets were prepared by direct compression method. Ac-Di-Sol was selected for the formulation from Crospovidone and Sodium starch Glycolate. Prepared tablets were evaluated for weight variation, uniformity of content, disintegration time and dissolution. Total nine batches were punched and B8 batch was taken optimized batch which had highest similarity with reference produce.
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